2-Methoxycarbonyl-Thiophene-3-Sulfonamide (Mst)
methyl 3-Sulfonyl amino-2-thiophenecarboxylate
CAS: 59337-93-8
Molecular Formula: C6H7NO4S2
2-Methoxycarbonyl-Thiophene-3-Sulfonamide (Mst) - Names and Identifiers
2-Methoxycarbonyl-Thiophene-3-Sulfonamide (Mst) - Physico-chemical Properties
| Molecular Formula | C6H7NO4S2 |
| Molar Mass | 221.25 |
| Density | 1.517±0.06 g/cm3(Predicted) |
| Melting Point | 123-124 °C(Solv: water (7732-18-5)) |
| Boling Point | 428.3±55.0 °C(Predicted) |
| Flash Point | 212.8°C |
| Vapor Presure | 1.53E-07mmHg at 25°C |
| pKa | 9.55±0.60(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.579 |
| Physical and Chemical Properties | This product is white crystalline material, insoluble in water, soluble in toluene, acetonitrile, ethanol and other organic solvents. |
2-Methoxycarbonyl-Thiophene-3-Sulfonamide (Mst) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36 - Irritating to the eyes R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| Hazard Class | IRRITANT |
2-Methoxycarbonyl-Thiophene-3-Sulfonamide (Mst) - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | 3-aminosulfonylthiophene-2-carboxylic acid methyl ester is an intermediate of the sulfonylurea herbicide thiosulfuron. Used for the synthesis of thiosulfuron-methyl herbicide, and also used for the synthesis of pharmaceutical products |
| production method | the preparation method is to add methyl 3-aminothiophene -2-carboxylate into the reaction kettle, then add acetic acid and hydrochloric acid, stir to a certain temperature (generally at -5 ℃), drop sodium nitrite aqueous solution into the reaction kettle, keep a certain temperature, drop for about 10h, and keep the temperature for 1h. In another reaction kettle, the above-mentioned diazo liquid and a certain amount of hydrochloric acid, acetic acid and copper chloride catalyst are added and stirred, cooled to a certain temperature, sulfur dioxide is introduced, the reaction time is about 8h, the temperature is kept for 8h, water is added for filtration, and the compound is sulfonyl chloride. Add 3-sulfonyl chlorothiophene -2-carboxylic acid methyl ester and a certain amount of solvent into the ammoniation kettle, stir and introduce ammonia gas until the temperature does not rise, about 6 h, keep the temperature for 1 h, pump into a water washing pot, wash with water, cool to a certain temperature, filter, delaminate, and recover the solvent from the organic layer to obtain the finished product. |
Last Update：2024-04-09 15:16:46
